NKT cells Research Paper Example | Topics and Well Written Essays - 1000 words

NKT cells - Research Paper ExampleImmunologists have been striving to unearth the connection between NKT cells and the inflammatory characteristics of asthma, in a weightlift to design new intervention strategies. This paper will review the biology of instinctive Killer T cells and the prevention strategies of asthma and allergic diseases. Biology of NKT Cells Natural Killer T cells form a subset of lymphocytes as scientists have described. Depending on the T-cell receptor repertoires, NKT cells fall into three categories. The first type of NKT cells is the classical NKT cells that exhibit hold T-cell receptors (Akbariet al 2006). Immunologists have been described type 1 NKT cells in mice and humans, with those in humans named invariant NKT cells. Type 2 is also available in some(prenominal) mice and humans but have a diverse range of T-cell receptors. However, type 2 faces a restriction from CD1d. The third type forms the independent category of NKT cells characterized as expres sing either Ly49 or NK1.1 (CD161 in humans). Moreover, it proved quite difficult to isolate this type of NKT cells. Immunologists have succeeded in isolating type 1 and associating it with the development of asthma. NKT cells stick in numerous similarities to Th2 Cells, which propel the processes that cause the development of asthma. ... However, the two types of cells exhibit different activation processes (Wohlleben&Erb, 2006). Processes Leading to the Development of Asthma and related Atopic Diseases Experts seeking to understand the immunologic processes that lead to the development of asthma, have described the process in detail. Asthma results from the Th2 responses taking place in the lungs. The production of Th2 responses result from the action of allergen specific CD4+. The buttocks of asthma development is that there must be activation of transcription factors from the downstream factors resulting to the production of Th2 effector cells. The effect of these processes i s the production of cytokines such as interleukins IL-4, IL-5, IL-9, and IL-13. Moreover, these processes trigger the recruitment of eosinophils and allergen specific immunoglobulin E by beta cells (Mallevaey et al, 2006). Granulation of eosinophils and mast cells occurs with as they indulge in a cross-linking with immunoglobulin E (igE). This causes the production of mucose and airway hyper-reactivity and a chronic inflaming of the airway. These are the central attributes of asthma.Processes that trigger Th2 responses often lead to airway hyper-reactivity and inflammation. Immunologists have highlighted that Th1 responses do not trigger this hyper-reactivity and inflammation defining asthma and other atopic diseases. There is evidence suggesting that children contacting bacterial infections that trigger Th1 responses in their earlier years have a less likelihood of develop asthma. NKT Cells and Asthma There is evidence that NKT cells have the potential to trigger Th2 responses t hat often lead to development of asthma and other atopic diseases. This is because of their ability to recognize glycolipid

-Issues with Chinesse Made goods (toys, food) Research Paper

-Issues with Chinesse Made goods (toys, food) - Research Paper Exampleorted recall of Stuffed Fun balls, during June 2006 to work on 2007, from dollar and other discount stores as these baby toys contained dangerous level of lead in the paint used by the Chinese maker. Similarly umteen childrens turquoise rings were recalled by the Central Distributing Company of Maryland, during May 2007, as the same contained dangerous levels of lead.(Jefferson, 2007)The wheat gluten that was imported into America from China has been engraft responsible for the contamination of food products that killed huge number of pets and dogs, during 2007. However, media reports inform that the person responsible for allowing the export of such food product was arrested and executed by the Chinese government. The Chinese company exporting contaminated wheat gluten for human and animal consumption has been banned by the US government. Fortunately no large exfoliation human tragedy was reported, due to such contamination.(Vujsa, 2007)In view of the ever increasing rejection of Chinese goods, due to above and other reasons, many Chinese business enterprise houses have incorporated corporate social responsibility and global law-abidance in their business models. The same include guarantee of high quality products and services by the business enterprises, among other issues.(Zhihai, 2007)Zhihai Zheng, Corporate Social Responsibility, International Management Review, Vol. 3 No. 1 2007, accessed on 8th March 2011 at

Business plan Essay Example | Topics and Well Written Essays - 1750 words - 3

Business plan - Essay Examplea leading bank in the United Kingdom which offers start-up loans to the tune of 25000.00 for young self-employed mountain who intend to start a business. We have applied for the same and are eligible for the loan. We shall be using these funds for initial start-up expense as substantially as carrying out day-to-day expenses. This loan will be for the period of 1 year after which we intend to request the bank for an overdraft facility1 (HSBC.co.uk, 2013)I care to believe that Ive reached a stage where I cant let ANYTHING outside my own self responsible for my negative states. Nothing in the external environment is 100% negative. Every situation, however bad, has its lessons n gifts. Its up to me to make use of any circumstance in a beneficial wayWe are under negotiations for the purchase of a commercial property located at 12, Regent Street, Leeds, LS6 (RIGHTMOVE.co.uk, 2013). This property will cost us 4,50,000. We intend to carry out further renovat ion and interiors to the tune of 2,50,000. The property is located is front-facing to the main road leading to Headingley Stadium and has immense potential for a eating place business.Ensure the building is classified under class A3 category which involves use of sale of food or drink for consumption on the premise (UK Statutory Instrument 1987 No. 764, Town & Country Planning Order 1987).Agustos is planned to be a casual restaurant-cum-lounge targeting the varied class of race staying in Leeds. Leeds also happens to be a student city From our research we found that people aged between 17 to 25 visits a restaurant every weekend. One of our main objectives is to provide nutritiously high-value meal at a comparatively low cost.Marketing Budget We intend to allocate about 2 % of the start-up cost for the purpose of marketing. We mostly intend to depend on word-of-mouth publicity. We will be spending most of our budget on print media and rabbet coupons.We intend to do our advertisin g in the

Alvar Nunez Cabeza de Vaca, Indians of the Rio Grande (1528-1536) Essay

Alvar Nunez Cabeza de Vaca, Indians of the Rio Grande (1528-1536) - Essay ExampleWe treated many satisfied patients who firmly believed in our abilities. The natives exceedingly respected us. Women treated us with mats and cooked food for us. The natives would abandon anything that was not blessed by us. As a result, we were supposed to breathe on and bless each share that was bought to us.Moreover, they would seek our advice for all important matters. During our expeditions, other people who feared us and believed firmly in our sacred powers welcomed us. They surrendered all their possessions to us that were distributed to those who were needy of them. During the expedition, we suffered a spread from malnutrition until Castillo and the Negro, left to look for food to a village beneath the river. Good news flowed from here, and the natives came to welcome them with food and water (Barker, pp. 15-20). However, as the natives and the Indians did not get on well, we had to follow th e league of the natives, leaving the Indians behind with their food. The natives celebrated our arrival, while we left the next day. The following night, I asked my mates to look for the Christians who were moving away from that luck of the country, who nevertheless refused due to the fatigue and weariness. However, I took off with my league in search of Christians. On our journey, we met four Christians who were astonished to see us I nonetheless, asked them to overtake us to their captain Diego de Alcaraz.

Effects of Media on Fear of Crime, Perception and Reality Essay

Effects of Media on Fear of Crime, Perception and Reality - adjudicate ExampleThe main part of upkeep of iniquity is the scope of emotions that is roused in people by the chance of oppression. While usual measures of concern about crime repeatedly prove between 35 percent and 55 percent of the residents of England show some type of apprehension about becoming a victim, surveys make known that a considerable number of individuals in fact worry for their personal soundlybeing on a daily basis. Contrary to usual perception, this level of fear has reduced since 1990s according to British Crime Surveys from 40% to 27% in 2003 in the United Kingdom. As a result, one can pick out between fear and broader apprehension. Nonetheless, it should come under notice that a number of individuals might be keener to disclose their uncertainties and vulnerabilities as comp ared to others. audience about possibilitys identifying others who have been persecuted - these are thought to increase insi ghts of the risk of oppression. This has been explained as a crime multiplier, or procedures functioning within the inhabit atmosphere that would reach the impacts of illegal happenings. much(prenominal) proof exists that hearing of friends or neighbours victimisation increases anxiety that in rule experiences of crime may play a stronger utilization in anxieties about victimisation than direct experience. Nonetheless, there is an advisory note several inhabitants of a locality merely know of offence indirectly by means of channels that may inflate, deflate, or distort the actual picture.... Nonetheless, it should come under notice that a number of individuals might be keener to disclose their uncertainties and vulnerabilities as compared to others. Hearing about happenings identifying others who have been persecuted - these are thought to increase insights of the risk of oppression (Flatley et al, pp. 1-220, 2010). This has been explained as a crime multiplier, or procedures fu nctioning within the inhabited atmosphere that would reach the impacts of illegal happenings. Such proof exists that hearing of friends or neighbours victimisation increases anxiety that indirect experiences of crime may play a stronger role in anxieties about victimisation than direct experience (McCluskey & Hooper, p. 173, 2001). Nonetheless, there is an advisory note several inhabitants of a locality merely know of offence indirectly by means of channels that may inflate, deflate, or distort the actual picture. Public views of the threat of crime are as well shaped strongly by mass media reporting. People pick up from media as well as interpersonal contact spreading representations of the criminal happening - the perpetrators, injured parties, cause, and signs of significant, irrepressible, and sensational crimes. The concept of stimulus likeness may be significant if the reader of a newspaper categorizes with the portrayed victim, or feels that their personal neighbourhood has s imilarity to the one explained, then the image of threat may be taken up, individualised and interpreted into personal security concerns. In addition, reports have indicated differences in perceptions of fear based on the type of newspapers read by locals in the United Kingdom (Simmons & Dodd, pp. 1-189, 2003). In a recent study, subjects

Personal Philosophy Paper Essay Example | Topics and Well Written Essays - 750 words

Personal Philosophy Paper - Essay Examplethe difficulties that they argon personnel casualty finished in life, and also by giving advice to the counselee on how to overcome the difficulties that they are going through in life.Question 4 Appropriate and Inappropriate goals of counselling. I view the following two gaols of counselling as appropriate,(a) assisting the counselling to discover themselves more so as to be able to overcome the difficulties that they are going through, (b) giving advice to the counselee on how to overcome and to adapt to the difficulties that they are going through in life (Goals of Counselling, web.). The two inappropriate goals of counselling are, (a) expecting the counselee to immediately overcome the difficulties that they are going through, (b) expecting the counselling to view the difficulties that they are going through as you view them.Question 5. The two important functions of a therapist are (a) serving the counselee to discover themselves more so as to be able to handle, in a better way, and to overcome the difficulties that they are going through in life, (b) to guide counselees pieces of professional and practical advice on how to overcome the difficulties that they are going through in life.Question 6. Essential characteristics of an effective client/therapist relationship. The common chord chief(prenominal) characteristics of an effective client/therapist are, (a) the relationship is based on trust (b) the relationship is open, in that the client and the therapist are open to each new(prenominal) (d) the relationship is cordial and friendly. The relationship between client and therapist is quit important in counselling because it determines the effectiveness of counselling.Question 7. The following are the three main values that I live by, (a) honesty, (b) respect, (c) confidentiality. These values will influence me as a counsellor because counselling requires that the counsellor or the therapist should be honest in his/her dealings with the counselee, the counsellor also should respect the counselee,

Reveiwing the titanic movie Review Example | Topics and Well Written Essays - 750 words

Reveiwing the titanic - Movie Review ExampleSimon Adams writes,The Titanics builders, Harland and Wolff, claimed that the ships system of watertight bulkheads made the vessel virtually unsinkable.(8) but the power of the ocean was awesome, once the ship was caught in its watery trap.The shooting of the movie is the saga of the technical expertise of the highest order. Once the ship sank, it began to move towards its resting place in the ocean bed. Most of the underwater shots of the wreckage of the ship were real. James Cameron hired in 1995 the Russian vessel Akademik Mstislav Keldysh and its two submersibles. The technical team worked at a knowledge of 12,500 feet below the North Atlantic. The special cameras and housings withstood the 6,000 pounds per square inch of water pressure. He made twelve dives of fifteen hours each and the cameras succeeded in storing 500 feet of consider only. Twelve minutes of footage was shot per dive. (www.imdb.)So, one can see introduction of many fake underwater shots in the movie.The sinking process of Titanic has pull together momentum. The ship is moving towards its final destination in a rapid pace and grandeur in consistent with its gigantic size. jacklight and Rose speed to the stern of the ship, along with many others, as it rises higher and higher. A priest is remembering God with the Rosary prayer. The passengers in freight, mob him. Jack and Rose make out to the stern and are clustered together and lean on the railings. Rose looks to Jack and says to him, Jack, this is where we first met (www.imdb)Cameron credits Kate Winslet with writing the heart-wrenching line during the final sinking. Jack kisses her forehead and presses her to him even more firmly. The ship now seems in a hurry to reach its final destination. It hangs in the air with a 30-degree angle in the midst of it and the water. People lose balance, slip and begin to fall/slide and crash into water. Many fall from the stern,